Some of the places and historical landmarks that are along the route would be:


Spruce ****, at 4,863 feet (1,482 m), is the highest point in the state of West Virginia and the summit of Spruce Mountain, the tallest mountain in the Alleghenies.
http://en.wikipedia.org/wiki/Spruce_Knob


The Robert C. Byrd Green Bank Telescope (GBT) is the world's largest fully steerable radio telescope and the world's largest land-based movable structure. It is part of the National Radio Astronomy Observatory (NRAO) site at Green Bank, West Virginia
http://en.wikipedia.org/wiki/Green_Bank_Telescope


Oakhurst Links/White Sulphur Springs/The Greenbrier,
http://en.wikipedia.org/wiki/White_S..._West_Virginia
America's first golf course was opened in 1884 in White Sulphur Springs and is called Oakhurst Links. Visitors to Oakhurst Links play the course just as golfers did in 1884. Golf at Oakhurst is played with replica 19th-century long-nose, hickory-shafted clubs and "guttie" *****, (made in St. Andrews Scotland exclusively for Oakhurst) hit from sand tees. The US National Hickory Championship tournament is held at Oakhurst annually in June.


The Greenbrier is also the site of a massive underground bunker that was meant to serve as an emergency shelter for the United States Congress during the Cold War.


Organ Cave, Significant fossil discoveries bear witness to the early natural history of Organ Cave: grizzly bear, nine-banded armadillo, sabre-tooth cat, reindeer and an Ice Age porcupine[7]. Organ Cave's human history is attested by flintarrowheads used by early American Indians. Evidence of early white settlers in the cave is suggested by the date "1704" scratched on a wall, but this may be a later addition since the first white settlers to Greenbrier County came only in the 1740s.
The cave has been used since before 1835 as a source for nitre (saltpeter) for the manufacture of gunpowder. During the American Civil War, Confederate soldiers under the command of General Robert E. Lee again mined the cave for nitre. The cave today has the nation's largest collection of Civil War-era saltpeter hoppers.
Organ Cave was first surveyed by members of the National Speleological Society in July 1948. For many years it was considered the longest cave in the world. As of 16 March 2009 (2009 -03-16)[update], the Organ Cave System had 38.452 miles (61.882 km) of surveyed cave passage making it the 35th longest cave in the world, the 8th longest in the United States, and the 2nd longest in West Virginia.

Tazewell County, Before the arrival of pioneers Tazewell County was a hunting ground for Native Americans. Although rare in the eastern United States, there are petroglyphs near the summit of Paintlick Mountain.
http://en.wikipedia.org/wiki/Tazewell_County,_Virginia



Natural Tunnel State Park is a Virginia state park, centered around the Natural Tunnel, a massive naturally-formed cave that is so large it is used as a railroad tunnel. It is located in the Appalachian Mountains near Duffield in Scott County, Virginia. (Just off the route, would require a detour)
http://en.wikipedia.org/wiki/Natural_Tunnel_State_Park



Rogersville is a town in Hawkins County, Tennessee, United States. It was settled in 1775 by the grandparents of Davy Crockett and is the second-oldest town in the state. It is named for its founder, Joseph Rogers.
Tennessee's oldest courthouse, first newspaper, and first post office are each located in Rogersville. Much of the Town is listed on the National Register of Historic Places.
In November 1863, during the American Civil War, Rogersville was the site of a battle between occupying Federal forces and invading Confederate troops. Union forces were encamped just outside the town. The Confederates, led by Brigadier General William E. Jones, were able to surprise the Union forces and pursue them across the Holston River and into Greene County. The Confederates held the town for the remainder of the War.
Sentiment in Rogersville was divided between loyalists, many of whom supported the efforts by many to get twenty-six East Tennessee counties to secede from the State and re-join the Union. Other Rogersvillians saw President Lincoln's invasion of Tennessee as an unprecedented invasion of their homes and an incursion by Federal power; these people became strong Confederates.
Partly because of the town's mixed loyalties, Rogersville was spared destruction during the war; indeed, many of the town's buildings were used by the different occupying armies.
http://en.wikipedia.org/wiki/Rogersville,_tn



Cherokee Reservoir, also known as Cherokee Lake, Cherokee Reservoir is named for the tribe of Native Americans who once inhabited the area. The great Indian warpath, once followed by Daniel Boone, crossed the basin now filled by the reservoir.
Cherokee Reservoir is a popular recreation destination. Along its shoreline are public access areas, county and municipal parks, commercial boat docks and resorts, a state park, and a state wildlife management area. There are many tent and trailer sites for campers.
http://en.wikipedia.org/wiki/Cherokee_Lake